Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
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Original Article

Volume 17, Number 10, October 2025, pages 550-555

Clinical Effects of the Concurrent Ingestion of Rosuvastatin and Magnesium Oxide: A Multicenter, Randomized, Parallel-Group Trial

Figures

Figure 1.
Figure 1. Study flowchart.
Figure 2.
Figure 2. Rate of change in the levels of T-Cho (a), HDL-C (b), LDL-C (c), and TG (d). Missing data: an = 9, bn = 4, cn = 1, dn = 2, en = 1, fn = 2. T-Cho: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglycerides.

Table

Table 1. Baseline Characteristics of Patients in the Control and Intervention Groups
 
Control (n = 25)Intervention (n = 20)P value
Missing data: an = 1, bn = 9, cn = 4, dn = 1, en = 2, fn = 1, gn = 2. BMI: body mass index; HDL-C: high-density lipoprotein cholesterol; IQR: interquartile range; LDL-C: low-density lipoprotein cholesterol; MgO: magnesium oxide; RSV: rosuvastatin; T-Cho: total cholesterol; TG: triglycerides.
Sex1.0000
  Male, n (%)18 (72.0)14 (70.0)
  Female, n (%)7 (28.0)6 (30.0)
Age (years), median (IQR)78 (69.0 - 82.0)76 (74.3 - 82.5)0.7058
BMI (kg/m2), median (IQR)23.7 (22.1 - 26.4)a23.9 (21.2 - 27.4)1.0000
Medication possession ratio (%), median (IQR)100 (97.70 - 100)100 (99.25 - 100)0.8949
RSV dose0.7482
  2.5 mg, n (%)15 (60.0)11 (55.0)
  5 mg, n (%)10 (40.0)8 (40.0)
  10 mg, n (%)0 (0)1 (5.0)
MgO dose0.4199
  330 mg, n (%)18 (72.0)15 (75.0)
  500 mg, n (%)5 (20.0)2 (10.0)
  660 mg, n (%)1 (4.0)3 (15.0)
  1,000 mg, n (%)1 (4.0)0 (0)
Administration timing0.3792
  After breakfast, n (%)16 (64.0)10 (50.0)
  After dinner, n (%)9 (36.0)10 (50.0)
T-Cho (mg/dL), median (IQR)159.5 (153.3 - 169.5)b152 (134.3 - 165.8)c0.2423
HDL-C (mg/dL), median (IQR)54.5 (48.3 - 62.8)d49 (43.0 - 57.3)e0.2681
LDL-C (mg/dL), median (IQR)77 (62.5 - 93.5)77.5 (65.0 - 94.5)0.7751
TG (mg/dL), median (IQR)113 (84.5 - 154.3)f105 (80.3 - 175.8)g0.8688