Serum Vitamin D Level Correlates Significantly With Leptin and Tumor Necrosis Factor-Alpha in Overweight Postmenopausal Women With Hypertension

Authors

  • Dina M. Qahwaji King Abdulaziz University, Faculty of Applied Medical Sciences, Department of Clinical Nutrition, Jeddah, Saudi Arabia https://orcid.org/0000-0002-8553-3169
  • Abdulhalim Salim Serafi Umm Al-Qura University, Faculty of Medicine, Department of Physiology, Makkah, Saudi Arabia https://orcid.org/0000-0001-7304-9268
  • Shalan Alaamri Jeddah University, Faculty of Medicine, Department of Medicine, Jeddah, Saudi Arabia https://orcid.org/0009-0001-8971-5699
  • Zahir Hussain Umm Al-Qura University, Faculty of Medicine, Department of Physiology, Makkah, Saudi Arabia https://orcid.org/0000-0003-4739-1865
  • Mohammed A. Bafail Umm Al-Qura University, Faculty of Medicine, Department of Physiology, Makkah, Saudi Arabia https://orcid.org/0000-0002-8702-2258
  • Christopher S. Gondi University of Illinois College of Medicine in Peoria, Medicine, Peoria, United States 5University of Illinois College of Medicine in Peoria, Surgery, Peoria, United States 6University of Illinois College of Medicine in Peoria, Health Sciences Education and Pathology, Peoria, United States 7University of Illinois Urbana Champaign, The Grainger College of Engineering, Urbana Champaign, United States https://orcid.org/0000-0002-3036-9920
  • Lusine Demirkhanyan University of Illinois College of Medicine in Peoria, Medicine, Peoria, United States 5University of Illinois College of Medicine in Peoria, Surgery, Peoria, United States https://orcid.org/0000-0002-3535-7996
  • Rizwana Sanaullah Waraich Biomedical Research Center, Department of Biomedical & Biological Sciences, Sohail University, Karachi-78400, Pakistan. https://orcid.org/0000-0002-5560-5053
  • Sumera Sohail University of Karachi, Faculty of Science, Department of Physiology, Karachi, Pakistan. https://orcid.org/0000-0002-1755-6748

DOI:

https://doi.org/10.14740/jocmr6148

Keywords:

Postmenopausal women, Overweight hypertensives, Serum vitamin D, Leptin, TNF-α

Abstract

Background: Association of serum vitamin D (vitD) with leptin (Lep) and tumor necrosis factor-alpha (TNF-α) is not precisely known in overweight hypertensive (OW-HT) postmenopausal (PMP) women. Hence, the present study was carried out to investigate the body mass index (BMI)-based correlation of serum vitD with Lep and TNF-α in OW-HT PMP women.

Methods: Women subjects in their early PMP (n = 346, age: 51 - 60 years) categorized into three groups had main inclusion criteria of specified range of age, BMI and blood pressure (BP). Enzyme-linked immunosorbent assay (ELISA) and other kit methods were employed to investigate the role of various variables in three subject groups (normal weight normotensive (NW-NT, n = 116, BMI (kg/m2): 22 - 24.9), normal weight hypertensive (NW-HT, n = 115, BMI: 22 - 24.9) and OW-HT (n = 115, BMI: 25 - 29.9) PMP women).

Results: A significant negative linear correlation of vitD with serum Lep and TNF-α, and a significant positive linear correlation of BMI with Lep and TNF-α in OW-HT PMP women were obtained. Significantly higher levels of serum Lep, TNF-α and interleukin-6 (IL-6) were found in OW-HT PMP women, as compared to NW-HT PMP women.

Conclusions: The present study suggests that decreased serum vitD levels correlate with the Lep and TNF-α in OW-HT PMP women. However, further studies may help understand the impact of vitD in cardiovascular events and the influencing factors in OW-HT PMP women.

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Published

2025-01-14

Issue

Vol. 17, No. 1, Jan 2025

Section

Original Article

License

Copyright (c) 2025 Journal of Clinical Medicine Research

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

1.
Qahwaji DM, Serafi AS, Alaamri S, et al. Serum Vitamin D Level Correlates Significantly With Leptin and Tumor Necrosis Factor-Alpha in Overweight Postmenopausal Women With Hypertension. J Clin Med Res. 2025;17(1):51-59. doi:10.14740/jocmr6148